TLR3 anticorps

N° du produit ABIN187555

Cet anticorps Souris Monoclonal détecte spécifiquement TLR3 dans WB, FACS, IP, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TLR3 anticorps (ABIN187555)

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 40C1285-6

Détail du produit anti-TLR3 anticorps

Specificité: Recognizes human Toll-like Receptor 3 (TLR3). Species Reactivity: Human and mouse. Others not tested.

Immunogène: Synthetic peptides derived from the cytoplasmic portion of human TLR3.

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Use 2-5 µg/106 cells for intracellular staining. Immunoprecipitation: Use 2 µg/106 transfected cells. Western blot: Use at 1-3 µg/mL. Immunohistochemistry: (paraffin sections) Immunocytochemistry The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 µg of liquid Protein G purified monoclonal antibody at 0.5 mg/mL in PBS containing protein stabilizer and 0.05% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur TLR3

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: CD283 / TLR3

Sujet: The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. TLR3 cDNA codes for a protein, ~120 kDa. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades