LEF1 anticorps (AA 256-297)

N° du produit ABIN187662

Cet anticorps anti-LEF1 est un anticorps Souris Monoclonal détectant LEF1 dans WB. Adapté pour Humain.

Aperçu rapide pour LEF1 anticorps (AA 256-297) (ABIN187662)

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LEF1 est non-conjugé

Application: Western Blotting (WB)

Clone: 2F4-1D10

Détail du produit anti-LEF1 anticorps

Épitope: AA 256-297

Specificité: This antibody detects all isoforms of LEF-1 by Western blot. Does not crossreact with TCF-1 or TCF-4. Species Reactivity: Human. Others not tested.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant full length LEF-1 protein.

Isotype: IgG1

Information d'application

Indications d'application: Western blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody 100 µg at 1.0 mg/mL. Provided as 0.2 µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur LEF1

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Autre désignation: LEF1

Sujet: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding