LEF1 anticorps

N° du produit ABIN187758

Cet anticorps anti-LEF1 est un anticorps Mouton Polyclonal détectant LEF1 dans WB. Adapté pour Humain.

Aperçu rapide pour LEF1 anticorps (ABIN187758)

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivité: Humain

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp LEF1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LEF1 anticorps

Specificité: Antibody reacts with human LEF-1, TCF-1, TCF-3, and TCF-4 Species Reactivity: Human, other species not tested.

Immunogène: Full length LEF

Information d'application

Indications d'application: Western blot: Use at 1-5 µg/ml The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1 mg/ml purified IgG in PBS with 0.02% sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur LEF1

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Autre désignation: LEF1

Sujet: Lymphoid Enhancer Factor - 1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3, and TCF-4) These factors play a crucial role in WNT/Wingless signaling, a transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also involved in the genesis of some cancers, including colon cancer, melanoma, and breast cancer. LEF-1 is expressed during development in many differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers, and the trigeminal nerve. It is redundant with TCF-1 (T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of polypeptides ranging in size between 55-57 kD on SDS-PAGE gels. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They may appear on Western blots as smaller immunoreactive forms.

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding