Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FANCL anticorps (C-Term)

FANCL Reactivité: Humain WB Hôte: Lapin Polyclonal RB23901 unconjugated
N° du produit ABIN1881336
  • Antigène Voir toutes FANCL Anticorps
    FANCL (Fanconi Anemia, Complementation Group L (FANCL))
    Épitope
    • 13
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 274-302, C-Term
    Reactivité
    • 38
    • 11
    • 9
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 3
    • 1
    Lapin
    Clonalité
    • 38
    Polyclonal
    Conjugué
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FANCL est non-conjugé
    Application
    • 26
    • 20
    • 4
    • 4
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This FANCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the C-terminal region of human FANCL.
    Clone
    RB23901
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FANCL Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Zhang, Zhao, Park, Wang, Dyer, Liu, Klee, McNiven, Tindall, Molina, Fei: "FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth." dans: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1524-34, (2010) (PubMed).

    García, Fernández, Osorio, Barroso, Fernández, Urioste, Benítez et al.: "Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer ..." dans: Carcinogenesis, Vol. 30, Issue 11, pp. 1898-902, (2009) (PubMed).

    Longerich, San Filippo, Liu, Sung: "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL." dans: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23182-6, (2009) (PubMed).

    McWilliams, Bamlet, de Andrade, Rider, Couch, Cunningham, Matsumoto, Rabe, Hammer, Petersen: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, (2009) (PubMed).

    Hess, Ameziane, Schuurhuis, Errami, Denkers, Kaspers, Cloos, Joenje, Reinhardt, Ossenkoppele, Zwaan, Waisfisz: "Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia." dans: Cellular oncology : the official journal of the International Society for Cellular Oncology, Vol. 30, Issue 4, pp. 299-306, (2008) (PubMed).

  • Antigène
    FANCL (Fanconi Anemia, Complementation Group L (FANCL))
    Autre désignation
    FANCL (FANCL Produits)
    Synonymes
    anticorps FAAP43, anticorps PHF9, anticorps POG, anticorps 2010322C19Rik, anticorps AW554273, anticorps B230118H11Rik, anticorps Phf9, anticorps Pog, anticorps gcd, anticorps Fanconi anemia complementation group L, anticorps Fanconi anemia, complementation group L, anticorps FANCL, anticorps Fancl
    Sujet
    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
    Poids moléculaire
    42905
    NCBI Accession
    NP_001108108, NP_060532
    UniProt
    Q9NW38
    Pathways
    Réparation de l'ADN
Vous êtes ici:
Support technique