Frataxin anticorps (N-Term)

N° du produit ABIN1881356

L’anticorps Lapin Polyclonal anti-Frataxin a été validé pour WB. Il convient pour détecter Frataxin dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour Frataxin anticorps (N-Term) (ABIN1881356)

Antigène: Frataxin (FXN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Frataxin est non-conjugé

Application: Western Blotting (WB)

Clone: RB41914

Détail du produit anti-Frataxin anticorps

Épitope: AA 36-64, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human FXN.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Frataxin (ABIN1881356)

Tsai, Barondeau: "Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex." dans: Biochemistry, Vol. 49, Issue 43, pp. 9132-9, (2010) (PubMed).

Thierbach, Drewes, Fusser, Voigt, Kuhlow, Blume, Schulz, Reiche, Glatt, Epe, Steinberg, Ristow: "The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals." dans: The Biochemical journal, Vol. 432, Issue 1, pp. 165-72, (2010) (PubMed).

Mariño, Zaldivar, Mesa, Mederos, Rodríguez, Gotay, Labrada, Ochoa, Macleod, Pérez: "Low predisposition to instability of the Friedreich ataxia gene in Cuban population." dans: Clinical genetics, Vol. 77, Issue 6, pp. 598-600, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Détails sur Frataxin

Antigène: Frataxin (FXN)

Autre désignation: FXN

Sujet: This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 23135

NCBI Accession: NP_000135, NP_001155178, NP_852090

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size