Frataxin anticorps (Internal Region)

N° du produit ABIN6261832

Détail du produit anti-Frataxin anticorps

Antigène: Frataxin (FXN)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Frataxin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: FXN Antibody detects endogenous levels of total FXN.

Homologie: Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human FXN, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Frataxin

Antigène: Frataxin (FXN)

Autre désignation: FXN (FXN Produits)

Synonymes: anticorps zgc:158218, anticorps LOC100284365, anticorps BcDNA:AT09528, anticorps CG8971, anticorps DFH, anticorps Dfh, anticorps Dmel\\CG8971, anticorps X25, anticorps dfh, anticorps CyaY, anticorps FA, anticorps FARR, anticorps FRDA, anticorps RGD1565754, anticorps Frda, anticorps frataxin, anticorps fxn, anticorps LOC100284365, anticorps TVAG_182150, anticorps fh, anticorps FTX1, anticorps FXN, anticorps Fxn

Sujet:

Description: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+, the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization, however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.

Gene: FXN

Poids moléculaire: 23kDa

ID gène: 2395

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size