LGMN anticorps (N-Term)

N° du produit ABIN1881495

Détail du produit anti-LGMN anticorps

Antigène: LGMN (Legumain (LGMN))

Épitope: AA 83-112, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGMN est non-conjugé

Application: Western Blotting (WB)

Homologie: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.

Clone: RB41868

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-LGMN (ABIN1881495)

Clerin, Shih, Deng, Hebert, Resmini, Shields, Feldman, Winkler, Albert, Maganti, Wong, Paulsen, Keith, Vlasuk, Pittman: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." dans: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).

Liu, Jang, Liu, Cheng, Peng, Yepes, Li, Matthews, Watts, Asano, Hara-Nishimura, Luo, Ye: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." dans: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).

Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: "Transcriptome analysis of human gastric cancer." dans: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, (2005) (PubMed).

Détails sur LGMN

Antigène: LGMN (Legumain (LGMN))

Autre désignation: LGMN (LGMN Produits)

Synonymes: anticorps AEP, anticorps LGMN1, anticorps PRSC1, anticorps AI746452, anticorps AU022324, anticorps Prsc1, anticorps MGC64351, anticorps cb173, anticorps cb460, anticorps sb:cb173, anticorps zgc:76953, anticorps wu:fa98g05, anticorps wu:fj92g08, anticorps lgmn, anticorps MGC88980, anticorps DELTA VACUOLAR PROCESSING ENZYME, anticorps DELTAVPE, anticorps delta vacuolar processing enzyme, anticorps legumain, anticorps legumain L homeolog, anticorps delta vacuolar processing enzyme, anticorps Legumain, anticorps LGMN, anticorps Lgmn, anticorps lgmn.L, anticorps lgmn, anticorps DELTA-VPE, anticorps MBOO_RS07785, anticorps Odosp_3582, anticorps LOC569153

Sujet: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Poids moléculaire: 49411

NCBI Accession: NP_001008530, NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades