LGMN anticorps (AA 199-312)

N° du produit ABIN7157971

Détail du produit anti-LGMN anticorps

Antigène: LGMN (Legumain (LGMN))

Épitope: AA 199-312

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGMN est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Legumain protein (199-312AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LGMN

Antigène: LGMN (Legumain (LGMN))

Autre désignation: LGMN (LGMN Produits)

Synonymes: anticorps AEP, anticorps LGMN1, anticorps PRSC1, anticorps AI746452, anticorps AU022324, anticorps Prsc1, anticorps MGC64351, anticorps cb173, anticorps cb460, anticorps sb:cb173, anticorps zgc:76953, anticorps wu:fa98g05, anticorps wu:fj92g08, anticorps lgmn, anticorps MGC88980, anticorps DELTA VACUOLAR PROCESSING ENZYME, anticorps DELTAVPE, anticorps delta vacuolar processing enzyme, anticorps legumain, anticorps legumain L homeolog, anticorps delta vacuolar processing enzyme, anticorps Legumain, anticorps LGMN, anticorps Lgmn, anticorps lgmn.L, anticorps lgmn, anticorps DELTA-VPE, anticorps MBOO_RS07785, anticorps Odosp_3582, anticorps LOC569153

Sujet:

Background: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Aliases: AEP antibody, Asparaginyl endopeptidase antibody, cysteine 1 antibody, Cysteine protease 1 antibody, EC 3.4.22.34 antibody, Legumain antibody, LGMN antibody, LGMN_HUMAN antibody, LGMN1 antibody, Protease antibody, Protease cysteine 1 (legumain) antibody, Protease cysteine 1 antibody, PRSC1 antibody

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades