NEU1 anticorps (AA 188-214)

N° du produit ABIN1881576

Cité dans 3 publications. Cet anticorps anti-NEU1 Polyclonal Lapin (Clone RB42166) (ABIN1881576) détecte spécifiquement NEU1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NEU1 anticorps (AA 188-214) (ABIN1881576)

Antigène: NEU1 (Sialidase 1 (Lysosomal Sialidase) (NEU1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEU1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB42166

Détail du produit anti-NEU1 anticorps

Épitope: AA 188-214

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human NEU1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-NEU1 (ABIN1881576)

Caciotti, Di Rocco, Filocamo, Grossi, Traverso, dAzzo, Cavicchi, Messeri, Guerrini, Zammarchi, Donati, Morrone: "Type II sialidosis: review of the clinical spectrum and identification of a new splicing defect with chitotriosidase assessment in two patients." dans: Journal of neurology, Vol. 256, Issue 11, pp. 1911-5, (2009) (PubMed).

Lai, Chen, Wu Chou, Chang, Kao, Huang, Weng, Chen, Hwu, Lu: "A longitudinal study of Taiwanese sialidosis type 1: an insight into the concept of cherry-red spot myoclonus syndrome." dans: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 16, Issue 8, pp. 912-9, (2009) (PubMed).

Bonten, Campos, Zaitsev, Nourse, Waddell, Lewis, Taylor, dAzzo: "Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization." dans: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28430-41, (2009) (PubMed).

Détails sur NEU1

Antigène: NEU1 (Sialidase 1 (Lysosomal Sialidase) (NEU1))

Autre désignation: NEU1

Sujet: The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Poids moléculaire: 45467

NCBI Accession: NP_000425

UniProt: Q99519

Pathways: SARS-CoV-2 Protein Interactome