PARK7/DJ1 anticorps (C-Term)

N° du produit ABIN1881625

Cet anticorps Lapin Polyclonal détecte spécifiquement PARK7/DJ1 dans WB. Il présente une réactivité envers Poisson zèbre (Danio rerio) et a été mentionné dans 2+ publications.

Aperçu rapide pour PARK7/DJ1 anticorps (C-Term) (ABIN1881625)

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARK7/DJ1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PARK7/DJ1 anticorps

Épitope: AA 120-149, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PARK7/DJ1 (ABIN1881625)

Bretaud, Allen, Ingham, Bandmann: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." dans: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).

Bai, Mullett, Garver, Hinkle, Burton: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." dans: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).

Détails sur PARK7/DJ1

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Autre désignation: park7

Sujet: Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.

Poids moléculaire: 19764

NCBI Accession: NP_001005938

UniProt: Q5XJ36

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport