ALIX anticorps (AA 541-570)

N° du produit ABIN1881644

L’anticorps Lapin Polyclonal anti-ALIX a été validé pour WB. Il convient pour détecter ALIX dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour ALIX anticorps (AA 541-570) (ABIN1881644)

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALIX est non-conjugé

Application: Western Blotting (WB)

Clone: RB41924

Détail du produit anti-ALIX anticorps

Épitope: AA 541-570

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PDCD6IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-570 amino acids from the Central region of human PDCD6IP.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ALIX (ABIN1881644)

Inuzuka, Suzuki, Kawasaki, Shibata, Wakatsuki, Maki: "Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition." dans: BMC structural biology, Vol. 10, pp. 25, (2010) (PubMed).

Shi, Opi, Lugari, Restouin, Coursindel, Parrot, Perez, Madore, Zimmermann, Corbeil, Huang, Arold, Collette, Morelli: "Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X." dans: The Biochemical journal, Vol. 431, Issue 1, pp. 93-102, (2010) (PubMed).

Irie, Inoue, Sakaguchi: "Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection." dans: Virology, Vol. 405, Issue 2, pp. 334-41, (2010) (PubMed).

Sette, Jadwin, Dussupt, Bello, Bouamr: "The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif." dans: Journal of virology, Vol. 84, Issue 16, pp. 8181-92, (2010) (PubMed).

Détails sur ALIX

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Autre désignation: PDCD6IP

Sujet: This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Poids moléculaire: 96023

NCBI Accession: NP_001155901, NP_037506

UniProt: Q8WUM4

Pathways: Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation