PDE6H anticorps (AA 4-33)

N° du produit ABIN1881645

Cité dans 4 publications. Cet anticorps anti-PDE6H Polyclonal Lapin (Clone RB40887) (ABIN1881645) détecte spécifiquement PDE6H dans WB. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour PDE6H anticorps (AA 4-33) (ABIN1881645)

Antigène: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE6H est non-conjugé

Application: Western Blotting (WB)

Clone: RB40887

Détail du produit anti-PDE6H anticorps

Épitope: AA 4-33

Homologie: B, Rat, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PDE6H (ABIN1881645)

Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." dans: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, (2005) (PubMed).

Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." dans: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, (2002) (PubMed).

Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." dans: Genomics, Vol. 32, Issue 1, pp. 121-4, (1996) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." dans: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Détails sur PDE6H

Antigène: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Autre désignation: PDE6H

Sujet: This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Poids moléculaire: 9074

NCBI Accession: NP_006196

UniProt: Q13956

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling