PDE8B anticorps (AA 296-324)

N° du produit ABIN1881646

Cet anticorps Lapin Polyclonal détecte spécifiquement PDE8B dans WB. Il présente une réactivité envers Souris et a été mentionné dans 3+ publications.

Aperçu rapide pour PDE8B anticorps (AA 296-324) (ABIN1881646)

Antigène: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE8B est non-conjugé

Application: Western Blotting (WB)

Clone: RB42219

Détail du produit anti-PDE8B anticorps

Épitope: AA 296-324

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PDE8B (ABIN1881646)

Horvath, Faucz, Finkielstain, Nikita, Rothenbuhler, Almeida, Mericq, Stratakis: "Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels." dans: Thyroid : official journal of the American Thyroid Association, Vol. 20, Issue 4, pp. 363-7, (2010) (PubMed).

Shields, Freathy, Knight, Hill, Weedon, Frayling, Hattersley, Vaidya: "Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy." dans: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 11, pp. 4608-12, (2009) (PubMed).

Bimpaki, Nesterova, Stratakis: "Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes." dans: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 153-61, (2009) (PubMed).

Détails sur PDE8B

Antigène: PDE8B (phosphodiesterase 8B (PDE8B))

Autre désignation: PDE8B

Sujet: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 98979

NCBI Accession: NP_001025022, NP_001025023, NP_001025024, NP_001025025, NP_003710

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process