PPM1F anticorps (AA 275-303)

N° du produit ABIN1881678

Détail du produit anti-PPM1F anticorps

Antigène: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Épitope: AA 275-303

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPM1F est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.

Clone: RB41919

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PPM1F (ABIN1881678)

Harvey, Banga, Ozer: "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts." dans: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24889-98, (2004) (PubMed).

Koh, Tan, Manser, Lim: "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family." dans: Current biology : CB, Vol. 12, Issue 4, pp. 317-21, (2002) (PubMed).

Tan, Chan, Tan, Yu: "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis." dans: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 44193-202, (2001) (PubMed).

Kitani, Ishida, Okuno, Takeuchi, Kameshita, Fujisawa: "Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase." dans: Journal of biochemistry, Vol. 125, Issue 6, pp. 1022-8, (1999) (PubMed).

Détails sur PPM1F

Antigène: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Autre désignation: PPM1F (PPM1F Produits)

Synonymes: anticorps 1110021B16Rik, anticorps 4933427B07Rik, anticorps CaMKPase, anticorps Popx2, anticorps mKIAA0015, anticorps CAMKP, anticorps FEM-2, anticorps POPX2, anticorps hFEM-2, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1F, anticorps protein phosphatase 1F (PP2C domain containing), anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1F, anticorps PPM1F, anticorps Ppm1f

Sujet: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Poids moléculaire: 49831

NCBI Accession: NP_055449

UniProt: P49593

Pathways: Positive Regulation of Endopeptidase Activity