CSNK2A1/CK II alpha anticorps (N-Term)

N° du produit ABIN1881717

Cet anticorps anti-CSNK2A1/CK II alpha est un anticorps Lapin Polyclonal détectant CSNK2A1/CK II alpha dans WB. Adapté pour Humain et Rat. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour CSNK2A1/CK II alpha anticorps (N-Term) (ABIN1881717)

Antigène: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSNK2A1/CK II alpha est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CSNK2A1/CK II alpha anticorps

Épitope: AA 28-50, N-Term

Homologie: B, C, M, Rb, X, E, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Rat Csnk2a1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-50 amino acids from the N-terminal region of Rat Csnk2a1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CSNK2A1/CK II alpha (ABIN1881717)

Li, Li, Müller, Otto, Dietz, von Harsdorf: "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC." dans: Molecular cell, Vol. 10, Issue 2, pp. 247-58, (2002) (PubMed).

Ahmed, Davis, Hanten, Lambert, McIvor, Goueli: "Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate." dans: Cellular & molecular biology research, Vol. 39, Issue 5, pp. 451-62, (1994) (PubMed).

Détails sur CSNK2A1/CK II alpha

Antigène: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Autre désignation: Csnk2a1

Sujet: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins.

Poids moléculaire: 45073

NCBI Accession: NP_446276

UniProt: P19139

Pathways: SARS-CoV-2 Protein Interactome