SENP1 anticorps (AA 262-289)

N° du produit ABIN1881788

L’anticorps Lapin Polyclonal anti-SENP1 a été validé pour WB. Il convient pour détecter SENP1 dans des échantillons de Souris. Il y a 5+ publications disponibles.

Aperçu rapide pour SENP1 anticorps (AA 262-289) (ABIN1881788)

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB40856

Détail du produit anti-SENP1 anticorps

Épitope: AA 262-289

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SENP1 (ABIN1881788)

Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." dans: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, (2010) (PubMed).

Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." dans: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, (2010) (PubMed).

Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." dans: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, (2010) (PubMed).

Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." dans: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, (2008) (PubMed).

Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." dans: Cell, Vol. 131, Issue 3, pp. 584-95, (2007) (PubMed).

Détails sur SENP1

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Autre désignation: Senp1

Sujet: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

Poids moléculaire: 72511

NCBI Accession: NP_659100

UniProt: P59110

Pathways: Positive Regulation of Endopeptidase Activity