SENP1 anticorps (AA 262-289)

N° du produit ABIN1881788

Détail du produit anti-SENP1 anticorps

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Épitope: AA 262-289

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.

Clone: RB40856

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SENP1 (ABIN1881788)

Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." dans: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, (2010) (PubMed).

Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." dans: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, (2010) (PubMed).

Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." dans: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, (2010) (PubMed).

Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." dans: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, (2008) (PubMed).

Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." dans: Cell, Vol. 131, Issue 3, pp. 584-95, (2007) (PubMed).

Détails sur SENP1

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Autre désignation: Senp1 (SENP1 Produits)

Synonymes: anticorps SuPr-2, anticorps 2310046A20Rik, anticorps D15Ertd528e, anticorps E330036L07Rik, anticorps suPr-2, anticorps senp1, anticorps senp1a, anticorps xsenp1, anticorps SENP1, anticorps Senp1, anticorps senp1b, anticorps SUMO1/sentrin specific peptidase 1, anticorps SUMO1/sentrin specific peptidase 1 S homeolog, anticorps sentrin/SUMO-specific protease 1, anticorps SUMO1/sentrin specific peptidase 1 L homeolog, anticorps SENP1, anticorps Senp1, anticorps senp1.S, anticorps senp1.L, anticorps senp1

Sujet: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

Poids moléculaire: 72511

NCBI Accession: NP_659100

UniProt: P59110

Pathways: Positive Regulation of Endopeptidase Activity