T Antigen (AA 15-43), (N-Term) anticorps

N° du produit ABIN1881864

Détail du produit

Antigène: T Antigen

Épitope: AA 15-43, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF)

Homologie: Chicken,Mouse (Murine)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Immunogène: This T antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human T.

Clone: RB41833

Information d'application

Indications d'application: WB: 1:1000,IF: 1:10-50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.39 mg/mL

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Référence

Jambhekar, Rekhi, Thorat, Dikshit, Agrawal, Puri: "Revisiting chordoma with brachyury, a \new age\" marker: analysis of a validation study on 51 cases."" dans: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1181-7, (2010) (PubMed).

Yang, Ng, Alcorta, Liebsch, Sheridan, Li, Goldstein, Parry, Kelley: "T (brachyury) gene duplication confers major susceptibility to familial chordoma." dans: Nature genetics, Vol. 41, Issue 11, pp. 1176-8, (2009) (PubMed).

Bondue, Lapouge, Paulissen, Semeraro, Iacovino, Kyba, Blanpain: "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification." dans: Cell stem cell, Vol. 3, Issue 1, pp. 69-84, (2008) (PubMed).

Oakley, Fuhrer, Seethala: "Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis." dans: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 12, pp. 1461-9, (2008) (PubMed).

Détail du antigène

Antigène: T Antigen

Sujet: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.

Synonyms: T, Brachyury protein, Protein T

NCBI Accession: NP_003172, NP_001257413

UniProt: O15178