TXN anticorps (C-Term)

N° du produit ABIN1881960

Cet anticorps anti-TXN est un anticorps Lapin Polyclonal détectant TXN dans WB et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour TXN anticorps (C-Term) (ABIN1881960)

Antigène: TXN (Thioredoxin (TXN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB42816

Détail du produit anti-TXN anticorps

Épitope: AA 66-94, C-Term

Homologie: B, M, Pig, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-TXN (ABIN1881960)

Zheng, Ma, Sun, Yin, Lin, Liu, Xu, Zeng: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." dans: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).

Détails sur TXN

Antigène: TXN (Thioredoxin (TXN))

Autre désignation: TXN

Sujet: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Poids moléculaire: 11737

NCBI Accession: NP_001231867, NP_003320

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis