TXNIP anticorps (AA 116-145)

N° du produit ABIN1881961

Cet anticorps Lapin Polyclonal détecte spécifiquement TXNIP dans WB et IHC (p). Il présente une réactivité envers Souris et a été mentionné dans 5+ publications.

Aperçu rapide pour TXNIP anticorps (AA 116-145) (ABIN1881961)

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXNIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB30652

Détail du produit anti-TXNIP anticorps

Épitope: AA 116-145

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-TXNIP (ABIN1881961)

Martin: "[Growing old]." dans: Revue médicale suisse, Vol. 6, Issue 256, pp. 1424, (2010) (PubMed).

Kwon, Lim, Han, Lee, Yoon, Nam, Choi, Kim, Won, Kim: "The role of vitamin D3 upregulated protein 1 in thioacetamide-induced mouse hepatotoxicity." dans: Toxicology and applied pharmacology, Vol. 248, Issue 3, pp. 277-84, (2010) (PubMed).

Kwon, Won, Suh, Jeon, Shao, Yoon, Chung, Kim, Kim, Nam, Yoon, Kim, Kim, Kim, Kim, Kim, Choi: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, (2010) (PubMed).

Ren, Shi, Wang, Li, Wu, Li, Zhang, Duan: "p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells." dans: FEBS letters, Vol. 584, Issue 15, pp. 3480-5, (2010) (PubMed).

Shao, Kim, Shin, Kim, Suh, Piao, Jeong, Lee, Yoon, Lim, Kim, Ahn, Choi: "TXNIP regulates germinal center generation by suppressing BCL-6 expression." dans: Immunology letters, Vol. 129, Issue 2, pp. 78-84, (2010) (PubMed).

Détails sur TXNIP

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Autre désignation: Txnip

Sujet: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Poids moléculaire: 44363

NCBI Accession: NP_001009935, NP_076208

UniProt: Q8BG60

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome