TXNIP anticorps (N-Term)

N° du produit ABIN1881962

L’anticorps Lapin Polyclonal anti-TXNIP a été validé pour WB. Il convient pour détecter TXNIP dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour TXNIP anticorps (N-Term) (ABIN1881962)

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXNIP est non-conjugé

Application: Western Blotting (WB)

Clone: RB41554

Détail du produit anti-TXNIP anticorps

Épitope: AA 1-30, N-Term

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TXNIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TXNIP.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-TXNIP (ABIN1881962)

Zhuo, Niu, Chen, Xin, Guo, Mao: "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts." dans: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31491-501, (2010) (PubMed).

Kwon, Won, Suh, Jeon, Shao, Yoon, Chung, Kim, Kim, Nam, Yoon, Kim, Kim, Kim, Kim, Kim, Choi: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, (2010) (PubMed).

Yu, Chai, He, Hagen, Luo: "Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate." dans: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25822-30, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Détails sur TXNIP

Antigène: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Autre désignation: TXNIP

Sujet: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Poids moléculaire: 43661

NCBI Accession: NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome