ULK1 anticorps (pSer556)

N° du produit ABIN1881980

L’anticorps Lapin Polyclonal anti-ULK1 a été validé pour DB. Il convient pour détecter ULK1 dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour ULK1 anticorps (pSer556) (ABIN1881980)

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK1 est non-conjugé

Application: Dot Blot (DB)

Clone: RB40759

Détail du produit anti-ULK1 anticorps

Épitope: pSer556

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ULK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S556 of human ULK1.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ULK1 (ABIN1881980)

Mercer, Kaliappan, Dennis: "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy." dans: Autophagy, Vol. 5, Issue 5, pp. 649-62, (2009) (PubMed).

Ganley, Lam, Wang, Ding, Chen, Jiang: "ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy." dans: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12297-305, (2009) (PubMed).

Jung, Jun, Ro, Kim, Otto, Cao, Kundu, Kim: "ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery." dans: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1992-2003, (2009) (PubMed).

Hosokawa, Hara, Kaizuka, Kishi, Takamura, Miura, Iemura, Natsume, Takehana, Yamada, Guan, Oshiro, Mizushima: "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy." dans: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1981-91, (2009) (PubMed).

Détails sur ULK1

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Autre désignation: ULK1

Sujet: Involved in autophagy. Required for autophagosome formation (By similarity). Target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13/KIAA0652 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex (By similarity). Phosphorylates ATG13/KIAA0652. Involved in axon growth (By similarity). Plays an essential role in neurite extension of cerebellar granule cells (By similarity).

Poids moléculaire: 112631

NCBI Accession: NP_003556

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy