FDPS anticorps (N-Term)

N° du produit ABIN1882080

Cet anticorps anti-FDPS est un anticorps Lapin Polyclonal détectant FDPS dans WB, IHC (p) et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour FDPS anticorps (N-Term) (ABIN1882080)

Antigène: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FDPS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB4783-4784

Détail du produit anti-FDPS anticorps

Épitope: AA 82-112, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of human FDPS.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:100. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FDPS (ABIN1882080)

Wilkin, Kutsunai, Edwards et al.: "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ..." dans: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4607-14, (1990) (PubMed).

Sheares, White, Molowa, Chan, Ding, Kroon, Bostedor, Karkas: "Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells." dans: Biochemistry, Vol. 28, Issue 20, pp. 8129-35, (1990) (PubMed).

Détails sur FDPS

Antigène: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Autre désignation: FDPS

Sujet: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Poids moléculaire: 48275

NCBI Accession: NP_001129293, NP_001129294, NP_001229753, NP_001229754, NP_001995

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation