PINK1 anticorps (AA 237-266)

N° du produit ABIN1882117

Détail du produit anti-PINK1 anticorps

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Épitope: AA 237-266

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).

Clone: RB7383

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PINK1 (ABIN1882117)

Mannam, Shinn, Srivastava, Neamu, Walker, Bohanon, Merkel, Kang, Dela Cruz, Ahasic, Pisani, Trentalange, West, Shadel, Elias, Lee: "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 7, pp. L604-19, (2014) (PubMed).

Geisler, Holmström, Skujat, Fiesel, Rothfuss, Kahle, Springer: "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1." dans: Nature cell biology, Vol. 12, Issue 2, pp. 119-31, (2010) (PubMed).

Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." dans: Archives of neurology, Vol. 61, Issue 12, pp. 1898-904, (2004) (PubMed).

Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: "Novel PINK1 mutations in early-onset parkinsonism." dans: Annals of neurology, Vol. 56, Issue 3, pp. 424-7, (2004) (PubMed).

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1 (PARK6) (PINK1 Produits)

Synonymes: anticorps BEST:GH23468, anticorps CG4523, anticorps Dmel\\CG4523, anticorps PINK, anticorps PINK1, anticorps dPINK1, anticorps dPink1, anticorps pink1, anticorps wu:fc39e12, anticorps zgc:101729, anticorps BRPK, anticorps PARK6, anticorps 1190006F07Rik, anticorps AU042772, anticorps AW557854, anticorps mFLJ00387, anticorps PTEN-induced putative kinase 1, anticorps PTEN induced putative kinase 1, anticorps Pink1, anticorps PINK1, anticorps pink1

Sujet: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Poids moléculaire: 62769

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy