ATG3 anticorps (C-Term)

N° du produit ABIN1882157

L’anticorps Lapin Polyclonal anti-ATG3 a été validé pour WB. Il convient pour détecter ATG3 dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour ATG3 anticorps (C-Term) (ABIN1882157)

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB7459

Détail du produit anti-ATG3 anticorps

Épitope: AA 168-197, C-Term

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human ATG3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG3 (ABIN1882157)

Radoshevich, Murrow, Chen, Fernandez, Roy, Fung, Debnath: "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death." dans: Cell, Vol. 142, Issue 4, pp. 590-600, (2010) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Détails sur ATG3

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Autre désignation: ATG3

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Poids moléculaire: 35864

NCBI Accession: NP_001265641, NP_071933

UniProt: Q9NT62

Pathways: Autophagy