LEF1 anticorps (AA 10-37)

N° du produit ABIN1882259

Il existe 3+ publications pour ce produit. L’anticorps anti-LEF1 Monoclonal Souris est utilisé pour la détection de LEF1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour LEF1 anticorps (AA 10-37) (ABIN1882259)

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LEF1 est non-conjugé

Application: Western Blotting (WB)

Clone: 661CT8-3-5

Détail du produit anti-LEF1 anticorps

Épitope: AA 10-37

Homologie: M, Rat

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: This LEF1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from human LEF1.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500~8000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-LEF1 (ABIN1882259)

Gutierrez, Tschumper, Wu, Shanafelt, Eckel-Passow, Huddleston, Slager, Kay, Jelinek: "LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis." dans: Blood, Vol. 116, Issue 16, pp. 2975-83, (2010) (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." dans: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, (2010) (PubMed).

Chen, Zhang, Pincus, Wu, Ricks, Liu, Sun, Maclaren, Lan: "Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 9, pp. 5047-54, (2010) (PubMed).

Détails sur LEF1

Antigène: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Autre désignation: LEF1

Sujet: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 44201

NCBI Accession: NP_001124185, NP_001124186, NP_001159591, NP_057353

UniProt: Q9UJU2

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding