RASGRP4 anticorps (AA 108-170)

N° du produit ABIN1885956

Cet anticorps anti-RASGRP4 Polyclonal Lapin (ABIN1885956) détecte spécifiquement RASGRP4 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RASGRP4 anticorps (AA 108-170) (ABIN1885956)

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-RASGRP4 anticorps

Épitope: AA 108-170

Purification: Purified by antigen-affinity chromatography.

Immunogène: Synthetic peptide contain a sequence corresponding to a region within amino acids 108 and 170 of Human RASGRP4

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur RASGRP4

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Autre désignation: RASGRP4

Sujet: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors.It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands.This protein was shown to activate H-Ras in a cation-dependent manner in vitro.Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways.Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development.Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]

Poids moléculaire: 75 kDa

ID gène: 115727

NCBI Accession: NM_170604, NP_733749

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling