CLP1 anticorps (AA 142-341)

N° du produit ABIN1886042

L’anticorps Lapin Polyclonal anti-CLP1 a été validé pour WB, IHC et IF. Il convient pour détecter CLP1 dans des échantillons de Humain.

Aperçu rapide pour CLP1 anticorps (AA 142-341) (ABIN1886042)

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CLP1 anticorps

Épitope: AA 142-341

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 142 and 341 of HEAB

Information d'application

Indications d'application: Suggested dilutions:
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur CLP1

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Autre désignation: HEAB

Sujet: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.Appears to have roles in both tRNA splicing and mRNA 3'-end formation.Component of the tRNA splicing endonuclease complex.Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA.Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation.Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC).However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Poids moléculaire: 48 kDa

ID gène: 10978

Pathways: Ribonucleoprotein Complex Subunit Organization