IL12RB1 anticorps (AA 57-458)

N° du produit ABIN1886561

L’anticorps anti-IL12RB1 Polyclonal Lapin est utilisé pour la détection de IL12RB1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour IL12RB1 anticorps (AA 57-458) (ABIN1886561)

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12RB1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL12RB1 anticorps

Épitope: AA 57-458

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 57 and 458 of Human IL12RB1

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur IL12RB1

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Sujet: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex.This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity.The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections.Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[provided by RefSeq]

Poids moléculaire: 73 kDa

ID gène: 3594

NCBI Accession: NM_005535, NP_005526

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation