BIRC7 anticorps (AA 264-280, AA 281-298)

N° du produit ABIN1886863

Cet anticorps Lapin Polyclonal détecte spécifiquement BIRC7 dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BIRC7 anticorps (AA 264-280, AA 281-298) (ABIN1886863)

Antigène: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-BIRC7 anticorps

Épitope: AA 264-280, AA 281-298

Specificité: A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.

Purification: Affinity chromatography purified via peptide column

Immunogène: Livin antibody was raised with a Synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin.This sequence is identical between a and b forms of the Livin proteins.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur BIRC7

Antigène: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Autre désignation: Livin

Sujet: Apoptosis, or programmed cell death, is related to many diseases, such as cancer.Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins.IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP.Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta.Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6.Livin has direct interaction with several caspases including caspase-3, -7, and -9.Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.The two isoforms of Livin appear to have different functions and tissue distributions.
Synonyms: KIAP

Poids moléculaire: 33 kDa

NCBI Accession: NP_071444