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CCL20 anticorps (APC)

CCL20 Reactivité: Humain FACS Hôte: Souris Monoclonal UCHL1 APC
N° du produit ABIN192399
  • Antigène Voir toutes CCL20 Anticorps
    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
    Reactivité
    • 57
    • 32
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 44
    • 24
    • 4
    • 1
    Souris
    Clonalité
    • 45
    • 28
    Monoclonal
    Conjugué
    • 33
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCL20 est conjugé à/à la APC
    Application
    • 47
    • 23
    • 17
    • 13
    • 13
    • 12
    • 10
    • 8
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody UCHL1 recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Human IL-2 dependent T cells
    Clone
    UCHL1
    Isotype
    IgG2a
    Top Product
    Discover our top product CCL20 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Ricciardi, Manfrini, Alfieri, Calamita, Crosti, Gallo, Müller, Pagani, Abrignani, Biffo: "The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling." dans: Cell metabolism, Vol. 28, Issue 6, pp. 895-906.e5, (2019) (PubMed).

    Akbar, Terry, Timms, Beverley, Janossy: "Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 7, pp. 2171-8, (1988) (PubMed).

    Beverley, Merkenschlager, Terry: "Phenotypic diversity of the CD45 antigen and its relationship to function." dans: Immunology. Supplement, Vol. 1, pp. 3-5, (1988) (PubMed).

    Terry, Brown, Beverley: "The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45." dans: Immunology, Vol. 64, Issue 2, pp. 331-6, (1988) (PubMed).

    Beverley: "Human T cell subsets." dans: Immunology letters, Vol. 14, Issue 4, pp. 263-7, (1987) (PubMed).

    Norton, Ramsay, Smith, Beverley, Isaacson: "Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues." dans: Journal of clinical pathology, Vol. 39, Issue 4, pp. 399-405, (1986) (PubMed).

    Smith, Brown, Rowe, Callard, Beverley: "Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1." dans: Immunology, Vol. 58, Issue 1, pp. 63-70, (1986) (PubMed).

  • Antigène
    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
    Autre désignation
    CD45R0 (CCL20 Produits)
    Synonymes
    anticorps MIP-3ALPHA, anticorps CCL20, anticorps si:dkey-150o13.1, anticorps CKb4, anticorps LARC, anticorps MIP-3-alpha, anticorps MIP-3a, anticorps MIP3A, anticorps SCYA20, anticorps ST38, anticorps MIP-3A, anticorps MIP-3[a], anticorps Scya20, anticorps exodus-1, anticorps C-C motif chemokine ligand 20, anticorps chemokine (C-C motif) ligand 20b, anticorps chemokine (C-C motif) ligand 20, anticorps CCL20, anticorps ccl20b, anticorps Ccl20
    Sujet
    CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.,PTPRCR, T200R0
    Pathways
    Phosphorylation & l'infection par le SRAS-CoV-2
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