MAGED1 anticorps (AA 20-224)

N° du produit ABIN1944790

Cet anticorps Souris Monoclonal détecte spécifiquement MAGED1 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour MAGED1 anticorps (AA 20-224) (ABIN1944790)

Antigène: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAGED1 est non-conjugé

Application: Western Blotting (WB)

Clone: 1305CT862-157-127

Détail du produit anti-MAGED1 anticorps

Épitope: AA 20-224

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This MAGED1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 20-224 amino acids from the Central region of human MAGED1.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-MAGED1 (ABIN1944790)

Wen, Xue, Qin, Yu, Zhang, Zhao, Gao, Gu, Li: "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation." dans: FEBS letters, Vol. 564, Issue 1-2, pp. 171-6, (2004) (PubMed).

Salehi, Roux, Kubu, Zeindler, Bhakar, Tannis, Verdi, Barker: "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis." dans: Neuron, Vol. 27, Issue 2, pp. 279-88, (2000) (PubMed).

Põld, Zhou, Chen, Hall, Vescio, Berenson: "Identification of a new, unorthodox member of the MAGE gene family." dans: Genomics, Vol. 59, Issue 2, pp. 161-7, (1999) (PubMed).

Détails sur MAGED1

Antigène: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Autre désignation: MAGED1

Sujet: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53 transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Poids moléculaire: 86161

ID gène: 9500

UniProt: Q9Y5V3

Pathways: Neurotrophin Signaling Pathway