Metabotropic Glutamate Receptor 6 anticorps

N° du produit ABIN1944817

Cet anticorps Lapin Polyclonal détecte spécifiquement Metabotropic Glutamate Receptor 6 dans WB et IHC. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour Metabotropic Glutamate Receptor 6 anticorps (ABIN1944817)

Antigène: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Metabotropic Glutamate Receptor 6 anticorps

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-Metabotropic Glutamate Receptor 6 (ABIN1944817)

Devi, Markandeya, Maddodi, Dhingra, Vardi, Balijepalli, Setaluri: "Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes." dans: Pigment cell & melanoma research, Vol. 26, Issue 3, pp. 348-56, (2013) (PubMed).

Dryja, McGee, Berson, Fishman, Sandberg, Alexander, Derlacki, Rajagopalan: "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 13, pp. 4884-9, (2005) (PubMed).

Hashimoto, Inazawa, Okamoto, Tagawa, Bessho, Honda, Nakanishi: "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6." dans: The European journal of neuroscience, Vol. 9, Issue 6, pp. 1226-35, (1997) (PubMed).

Détails sur Metabotropic Glutamate Receptor 6

Antigène: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Autre désignation: mGluR6

Sujet: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

Poids moléculaire: 95468 Da

ID gène: 2916

UniProt: O15303