ATG4D anticorps (C-Term)

N° du produit ABIN1944848

Détail du produit anti-ATG4D anticorps

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Épitope: AA 441-470, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4D est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the C-terminal region of human ATG4D.

Clone: RB7567

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG4D (ABIN1944848)

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Melvin: "Make Milwaukee safe for babies: the Child Welfare Commission and the development of urban health centers, 1911-1912." dans: Journal of the West, Vol. 17, Issue 2, pp. 83-93, (1980) (PubMed).

Pontén, Westermark: "Properties of human malignant glioma cells in vitro." dans: Medical biology, Vol. 56, Issue 4, pp. 184-93, (1978) (PubMed).

Westermark, Pontén, Hugosson: "Determinants for the establishment of permanent tissue culture lines from human gliomas." dans: Acta pathologica et microbiologica Scandinavica. Section A, Pathology, Vol. 81, Issue 6, pp. 791-805, (1974) (PubMed).

Détails sur ATG4D

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Autre désignation: ATG4D (ATG4D Produits)

Synonymes: anticorps APG4-D, anticorps APG4D, anticorps AUTL4, anticorps 9830134P12Rik, anticorps Apg4d, anticorps Atg4dl, anticorps Autl4, anticorps apg4d, anticorps autophagy related 4D cysteine peptidase, anticorps autophagy related 4D, cysteine peptidase, anticorps autophagy related 4D, cysteine peptidase L homeolog, anticorps ATG4D, anticorps Atg4d, anticorps atg4d.L

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Poids moléculaire: 52922

ID gène: 84971

NCBI Accession: NP_001268433, NP_116274

UniProt: Q86TL0

Pathways: Autophagy