BIM anticorps (Ser65)
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- Antigène Voir toutes BIM (BCL2L11) Anticorps
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
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Épitope
- Ser65
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BIM est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- BIM antibody detects endogenous levels of total BIM protein.
- Purification
- Affinity Chromatography using epitope-specific immunogen.
- Immunogène
- The antiserum was produced against synthesized non-phosphopeptide derived from Mouse BIM around the phosphorylation site of Serine 65 (P-A-Sp-P-G).
- Top Product
- Discover our top product BCL2L11 Anticorps primaire
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- Indications d'application
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Immunohistochemistry: 1/50approx. 1/100. Western Blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
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- Antigène
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
- Abstract
- BCL2L11 Produits
- Synonymes
- anticorps bim, anticorps BAM, anticorps BIM, anticorps BOD, anticorps 1500006F24Rik, anticorps Bim, anticorps Bod, anticorps BimL, anticorps BIMEL, anticorps BCL2-like 11, anticorps BCL2 like 11, anticorps BCL2-like 11 (apoptosis facilitator), anticorps bcl2l11, anticorps BCL2L11, anticorps Bcl2l11
- Sujet
- Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis.Synonyms: BCL2L11, BIM, Bcl2-L-11, Bcl2-interacting mediator of cell death, BimEL, BimL, BimS
- ID gène
- 10018
- NCBI Accession
- NP_001191035
- UniProt
- O43521
- Pathways
- Signalisation PI3K-Akt, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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