CD161 anticorps

N° du produit ABIN1981864

Cet anticorps Souris Monoclonal détecte spécifiquement CD161 dans FACS, WB et IHC (fro). Il présente une réactivité envers Humain et Non-Human Primate et a été mentionné dans 4+ publications.

Aperçu rapide pour CD161 anticorps (ABIN1981864)

Antigène: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD161 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: HP-3G10

Détail du produit anti-CD161 anticorps

Fonction: Anti-Hu CD161 Purified

Specificité: The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: human NK cells

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD161 (ABIN1981864)

Tresoldi, DellAlbani, Stabilini, Jofra, Valle, Gagliani, Bondanza, Roncarolo, Battaglia: "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells." dans: Haematologica, Vol. 96, Issue 9, pp. 1357-65, (2011) (PubMed).

Germain, Meier, Jensen, Knapnougel, Poupon, Lazzari, Neisig, Håkansson, Dong, Wagtmann, Galsgaard, Spee, Braud: "Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses." dans: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 37964-75, (2011) (PubMed).

Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: "Gender specificity of altered human immune cytokine profiles in aging." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 9, pp. 3580-9, (2010) (PubMed).

Pozo, Valés-Gómez, Mavaddat, Williamson, Chisholm, Reyburn: "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 4, pp. 2397-406, (2006) (PubMed).

Détails sur CD161

Antigène: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Autre désignation: CD161

Sujet: Killer cell lectin like receptor B1,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, KLRB1, CLEC5B

ID gène: 3820

UniProt: Q12918