CD161 anticorps (PE)

N° du produit ABIN1981890

Détail du produit anti-CD161 anticorps (PE)

Antigène: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD161 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: human NK cells

Clone: HP-3G10

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD161 (PE) (ABIN1981890)

Wong, Akilimali, Govender, Sullivan, Cosgrove, Pillay, Lewinsohn, Bishai, Walker, Ndungu, Klenerman, Kasprowicz: "Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection." dans: PLoS ONE, Vol. 8, Issue 12, pp. e83474, (2014) (PubMed).

Tresoldi, DellAlbani, Stabilini, Jofra, Valle, Gagliani, Bondanza, Roncarolo, Battaglia: "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells." dans: Haematologica, Vol. 96, Issue 9, pp. 1357-65, (2011) (PubMed).

Germain, Meier, Jensen, Knapnougel, Poupon, Lazzari, Neisig, Håkansson, Dong, Wagtmann, Galsgaard, Spee, Braud: "Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses." dans: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 37964-75, (2011) (PubMed).

Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: "Gender specificity of altered human immune cytokine profiles in aging." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 9, pp. 3580-9, (2010) (PubMed).

Pozo, Valés-Gómez, Mavaddat, Williamson, Chisholm, Reyburn: "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 4, pp. 2397-406, (2006) (PubMed).

Détails sur CD161

Antigène: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Autre désignation: CD161 (KLRB1 Produits)

Synonymes: anticorps NKR-P1, anticorps KLRB1, anticorps 4930431A04Rik, anticorps Gm4696, anticorps Klrb1g, anticorps Klrb6, anticorps Ly-55, anticorps Ly55, anticorps NKR-P1G, anticorps Nkrp-1e, anticorps Nkrp1g, anticorps CD161, anticorps CLEC5B, anticorps NKR, anticorps NKR-P1A, anticorps NKRP1A, anticorps hNKR-P1A, anticorps Klrb1d, anticorps Klrb1f, anticorps Nkr-p1e, anticorps killer cell lectin like receptor B1, anticorps killer cell lectin-like receptor subfamily B member 1, anticorps killer cell lectin-like receptor subfamily B, member 1, anticorps KLRB1, anticorps Klrb1

Sujet: Killer cell lectin like receptor B1,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, KLRB1, CLEC5B

ID gène: 3820

UniProt: Q12918