Endothelin 1 anticorps (C-Term)

N° du produit ABIN198265

Cet anticorps Souris Monoclonal détecte spécifiquement Endothelin 1 dans IHC, RIA et IHC (fro). Il présente une réactivité envers Humain et Singe.

Aperçu rapide pour Endothelin 1 anticorps (C-Term) (ABIN198265)

Antigène: Endothelin 1 (EDN1)

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Endothelin 1 est non-conjugé

Application: Immunohistochemistry (IHC), Radioimmunoassay (RIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 1C4

Détail du produit anti-Endothelin 1 anticorps

Épitope: C-Term

Specificité: Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10 % reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0 mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.

Purification: Protein A purified

Immunogène: C-terminal fragment of human endothelin 1.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.2, 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Short term: -20°C
Long term: -20°C.

Détails sur Endothelin 1

Antigène: Endothelin 1 (EDN1)

Autre désignation: EDN1 / Endothelin 1

Sujet: Name/Gene ID: EDN1
Family: Hormone

Synonyms: EDN1, Endothelin 1, Endothelin-1, ET1, Preproendothelin-1, PPET1, HDLCQ7

ID gène: 1906

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size