beta Amyloid anticorps

N° du produit ABIN1990945

Cet anticorps Souris Monoclonal détecte spécifiquement beta Amyloid dans ELISA, DB et IL. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour beta Amyloid anticorps (ABIN1990945)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: ELISA, Dot Blot (DB), Immunolocalization (IL)

Clone: 3E5-F8

Détail du produit anti-beta Amyloid anticorps

Fonction: Anti-mAB-O | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 3E5,F8)

Réactivité croisée (Details): Human
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Homologie: Mouse,Bovine,Chicken,Dog,Porcine,Rabbit

Purification: Immunogen affinity purified serum

Immunogène: Synthetic peptide chosen from human Abeta (1-42) protein.

Isotype: IgG1, kappa

Information d'application

Indications d'application: 10 μg/mL (IL), 1-2 μg/mL (Dot), 1 μg/mL (ELISA capture)

Commentaires:

Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with primary antibody and antibody binding was visualized with IgG Preoxidase Reagent Kit.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 50 μL of sterile water

Buffer: Immunogen affinity purified serum in PBS pH 7.4.

Conseil sur la manipulation: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Stock: -20 °C

Stockage commentaire: Store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Abeta

Sujet: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein. Recent findings however suggest that smaller oligomeric forms of Abeta, formed in parallel to the amyloid plaques, excert the predominant tissue damaging effect.Specific identification of the oligomeric forms is as a consequence of great interest. Based on a recently published technique a highly oligomer-specific antibody (mAB-O), targeting Abeta oligomers while omitting reactivity towards the monomeric and fibrillar counterpart, has been developed.

Poids moléculaire: 4.5 kDa

Pathways: Inflammasome