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Retinoblastoma Protein (Rb) anticorps (Cleavage Site)

Cet anticorps anti-Retinoblastoma Protein (Rb) est un anticorps Souris Monoclonal détectant Retinoblastoma Protein (Rb) dans WB et IHC. Adapté pour Humain et Souris.
N° du produit ABIN207915

Aperçu rapide pour Retinoblastoma Protein (Rb) anticorps (Cleavage Site) (ABIN207915)

Antigène

Voir toutes Retinoblastoma Protein (Rb) (Rb Protein) Anticorps
Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivité

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Humain, Souris

Hôte

  • 124
  • 24
Souris

Clonalité

  • 122
  • 26
Monoclonal

Conjugué

  • 86
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Cet anticorp Retinoblastoma Protein (Rb) est non-conjugé

Application

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Western Blotting (WB), Immunohistochemistry (IHC)

Clone

172C1094
  • Épitope

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    Cleavage Site

    Specificité

    Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).

    Purification

    Protein G purified

    Immunogène

    A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.

    Type of Immunogen: Synthetic peptide

    Isotype

    IgG1
  • Indications d'application

    Approved: IHC, WB (2 μg/mL)

    Not recommended for: IHC-P

    Commentaires

    Target Species of Antibody: Human

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    PBS, 0.02 % sodium azide.

    Agent conservateur

    Sodium azide

    Précaution d'utilisation

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Stock

    4 °C,-80 °C

    Stockage commentaire

    Short term: 4°C
    Long term: -70°C.
  • Antigène

    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

    Autre désignation

    RB1 / Retinoblastoma / RB

    Sujet

    Name/Gene ID: RB1

    Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110

    ID gène

    5925

    UniProt

    P06400

    Pathways

    Mitotic G1-G1/S Phases
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