Retinoblastoma Protein (Rb) anticorps (AA 586-615)

N° du produit ABIN3032465

L’anticorps anti-Retinoblastoma Protein (Rb) Polyclonal Lapin est utilisé pour la détection de Retinoblastoma Protein (Rb) dans des échantillons de Humain. Il a été validé pour WB, IHC, ELISA et IF.

Aperçu rapide pour Retinoblastoma Protein (Rb) anticorps (AA 586-615) (ABIN3032465)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Protein (Rb) est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Retinoblastoma Protein (Rb) anticorps

Épitope: AA 586-615

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 586-615 from the human protein was used as the immunogen for this Rb antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Retinoblastoma Protein (Rb)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Autre désignation: Rb (Retinoblastoma)

Sujet: The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (Rb) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases