GPR161 anticorps (AA 121-220) (Biotin)

N° du produit ABIN2174756

L’anticorps Lapin Polyclonal anti-GPR161 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter GPR161 dans des échantillons de Humain.

Aperçu rapide pour GPR161 anticorps (AA 121-220) (Biotin) (ABIN2174756)

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR161 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GPR161 anticorps (Biotin)

Épitope: AA 121-220

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GPR161

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GPR161

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Autre désignation: GPR161

Sujet:

Synonyms: RE2, G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161

Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

ID gène: 23432

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process