LRP5 anticorps (AA 500-550) (PE)

N° du produit ABIN2177409

Cet anticorps anti-LRP5 est un anticorps Lapin Polyclonal détectant LRP5 dans . Adapté pour Humain, Souris et Rat.

Aperçu rapide pour LRP5 anticorps (AA 500-550) (PE) (ABIN2177409)

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP5 est conjugé à/à la PE

Application: Veuillez nous consulter SVP

Détail du produit anti-LRP5 anticorps (PE)

Épitope: AA 500-550

Specificité: This antibody will recognize LRP6 due to high sequence similarity.

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LRP5

Isotype: IgG

Information d'application

Commentaires:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C

Date de péremption: 12 months

Détails sur LRP5

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Autre désignation: Lrp5

Sujet:

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Subcellular location: Extracellular

Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

ID gène: 4041

UniProt: O75197

Pathways: Signalisation WNT, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation