Complement C4 anticorps

N° du produit ABIN2191789

Détail du produit anti-Complement C4 anticorps

Antigène: Complement C4 (C4) (Complement 4 (C4))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement C4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée (Details): Cross reactivity: C4b : Yes, C4d : Yes

Stérilité: 0.2 μm filtered

Clone: 16D2

Isotype: IgG2a

Information d'application

Indications d'application: For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive T-cell regions of mouse spleen control

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-Complement C4 (ABIN2191789)

Murata, Fox-Talbot, Qian, Takahashi, Stahl, Baldwin, Wasowska: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." dans: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).

Paul, Pozdnyakova, Mitchell, Carroll: "Anti-DNA autoreactivity in C4-deficient mice." dans: European journal of immunology, Vol. 32, Issue 9, pp. 2672-9, (2002) (PubMed).

Détails sur Complement C4

Antigène: Complement C4 (C4) (Complement 4 (C4))

Autre désignation: c4 (C4 Produits)

Synonymes: anticorps C4B1, anticorps C4B12, anticorps C4B2, anticorps C4B3, anticorps C4B5, anticorps C4BD, anticorps C4B_2, anticorps C4F, anticorps CH, anticorps CO4, anticorps CPAMD3, anticorps C4, anticorps C4A2, anticorps C4A3, anticorps C4A4, anticorps C4A6, anticorps C4AD, anticorps C4S, anticorps CPAMD2, anticorps RG, anticorps C4-1, anticorps C4b, anticorps C4-2, anticorps Slp, anticorps Ss, anticorps complement C4B (Chido blood group), anticorps complement C4A (Rodgers blood group), anticorps complement component 4A (Rodgers blood group), anticorps complement 4, anticorps complement component 4A, anticorps complement component 4B (Chido blood group), anticorps C4B, anticorps C4A, anticorps C4a, anticorps C4, anticorps C4b

Sujet: The monoclonal antibody 16D2 recognizes mouse complement factor C4, formerly known as Gg protein, which consists of an alpha-, beta-, and gamma-chain. The classical pathway of complement and the Mannose binding lectin activation pathway converge at C4. C1s, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. Subsequently, C4b can be cleaved to C4c and C4d by other serum enzymes. The monoclonal antibody 16D2 reacts with intact C4, C4b and C4d. C4 is an acute phase protein that is produced by hepatocytes, monocytes and intestinal epithelial cells and can be used in experimental animals as a marker for activation of the classical complement pathway. Recent studies have demonstrated an association between graft rejection and C4d deposition in a mouse model for cardiac transplantation. Aliases Complement component 4 Immunogen Thymocytes decorated with Thy-1 antibody and complement components

Pathways: Système du Complément