Ficolin 2 anticorps

N° du produit ABIN2191965

Détail du produit anti-Ficolin 2 anticorps

Antigène: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ficolin 2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Réactivité croisée (Details): Cross reactivity: Rat : Yes

Stérilité: 0.2 μm filtered

Clone: GN4

Isotype: IgG1

Information d'application

Indications d'application: For immunohistochemistry, immunoprecipitation and immuno assays, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-Ficolin 2 (ABIN2191965)

Matsushita, Kuraya, Hamasaki, Tsujimura, Shiraki, Fujita: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).

Matsushita, Endo, Hamasaki, Fujita: "Activation of the lectin complement pathway by ficolins." dans: International immunopharmacology, Vol. 1, Issue 3, pp. 359-63, (2001) (PubMed).

Détails sur Ficolin 2

Antigène: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Autre désignation: Ficolin-2 (FCN2 Produits)

Synonymes: anticorps EBP-37, anticorps FCNL, anticorps P35, anticorps ficolin-2, anticorps Fcn2, anticorps FCN1, anticorps fcn2, anticorps fcn2.S, anticorps ficolin 2, anticorps ficolin B, anticorps ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), anticorps ficolin 2 L homeolog, anticorps FCN2, anticorps Fcnb, anticorps fcn2.L

Sujet: The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2 - MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2 also shows opsonic activity. Aliases Ficolin-2/P35, L-ficolin, ficolin L, EBP-37 or hucolin

Pathways: Système du Complément