Transferrin Receptor anticorps

N° du produit ABIN2192003

L’anticorps Souris Monoclonal anti-Transferrin Receptor a été validé pour FACS, WB, IP, IHC (fro) et IA. Il convient pour détecter Transferrin Receptor dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour Transferrin Receptor anticorps (ABIN2192003)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Clone: 3B8 2A1

Détail du produit anti-Transferrin Receptor anticorps

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-Transferrin Receptor (ABIN2192003)

Vogt, Blackwell, Giannetti, Bjorkman, Enns: "Heterotypic interactions between transferrin receptor and transferrin receptor 2." dans: Blood, Vol. 101, Issue 5, pp. 2008-14, (2003) (PubMed).

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Sujet: Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45 % identity with TfR2.

Pathways: Transition Metal Ion Homeostasis