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MARCO anticorps

MARCO Reactivité: Humain WB, IP, IF, FACS, IHC (fro), Func Hôte: Souris Monoclonal PLK-1 unconjugated
N° du produit ABIN2192057
  • Antigène Voir toutes MARCO Anticorps
    MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
    Reactivité
    • 13
    • 6
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 12
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 12
    • 3
    • 1
    Monoclonal
    Conjugué
    • 15
    • 1
    Cet anticorp MARCO est non-conjugé
    Application
    • 14
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Réactivité croisée (Details)
    Cross reactivity: Bovine : Yes, Chicken : No
    Stérilité
    0.2 μm filtered
    Clone
    PLK-1
    Isotype
    IgG3
    Top Product
    Discover our top product MARCO Anticorps primaire
  • Indications d'application
    For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Human alveolar macrophages control Negative All other human cells control
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Stock
    4 °C
    Stockage commentaire
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Arredouani, Palecanda, Koziel, Huang, Imrich, Sulahian, Ning, Yang, Pikkarainen, Sankala, Vargas, Takeya, Tryggvason, Kobzik: "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 9, pp. 6058-64, (2005) (PubMed).

    Bunn, Kobzik, Grigg: "MARCO expression on pediatric alveolar macrophages." dans: Cytometry. Part B, Clinical cytometry, Vol. 60, Issue 1, pp. 54-6, (2004) (PubMed).

    Palecanda, Kobzik: "Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors." dans: Current molecular medicine, Vol. 1, Issue 5, pp. 589-95, (2002) (PubMed).

  • Antigène
    MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
    Autre désignation
    Marco (MARCO Produits)
    Synonymes
    anticorps AI323439, anticorps Ly112, anticorps Scara2, anticorps SCARA2, anticorps macrophage receptor with collagenous structure, anticorps MARCO, anticorps Marco
    Sujet
    The monoclonal antibody PLK-1 recognizes the macrophage receptor with collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens. The monoclonal antibody PLK-1 binds specifically to MARCO, and has been shown to partially block ligand binding. Aliases SCARA2, scavenger receptor class A member 2, macrophage receptor with collagenous structure Immunogen Human alveolar macrophages (recognizes domain V between residues 420 and 431)
    Pathways
    Activation of Innate immune Response
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