TREM1 anticorps

N° du produit ABIN2192226

Cet anticorps anti-TREM1 est un anticorps Souris Monoclonal détectant TREM1 dans WB, FACS, Func et IA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour TREM1 anticorps (ABIN2192226)

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func), Immunoassay (IA)

Clone: 6B1

Détail du produit anti-TREM1 anticorps

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-TREM1 (ABIN2192226)

Radsak, Taube, Haselmayer, Tenzer, Salih, Wiewrodt, Buhl, Schild: "Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease." dans: Clinical & developmental immunology, Vol. 2007, pp. 52040, (2008) (PubMed).

Haselmayer, Grosse-Hovest, von Landenberg, Schild, Radsak: "TREM-1 ligand expression on platelets enhances neutrophil activation." dans: Blood, Vol. 110, Issue 3, pp. 1029-35, (2007) (PubMed).

Détails sur TREM1

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Autre désignation: Triggering Receptor Expressed On Myeloid Cells 1

Sujet: (TREM-1). TREM-1 is a transmembrane glycoprotein belonging to a family related to the natural killer cell receptors. TREM-1 is an important activating receptor, of 26 kDa, involved in the innate inflammatory response and in sepsis. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonoistic stage and at high levels on neutrophil granulocytes (PMN), monocytes, and macrophage subsets. The expression of TREM-1 is upregulated by microbial products, that is, by toll-like receptor ligands such as lipoteichoic acid (LTA) of Gram-positive or lipopolysaccharide (LPS) of Gram-negative bacteria. Ligation of TREM-1 is synergistic with TLR agonists on the activation of receptor bearing cells. Platelets express a natural ligand for TREM-1. Receptor ligation activates the full repertoire of effector functions. TREM-1 is also produced in a soluble form (sTREM-1) of 17 kDa which is released in humans after endotoxin exposition or in patients suffering from severe pneumonia or sepsis. sTREM-1 can be measured in biological fluids and may be useful as a diagnostic tool. The monoclonal antibody 6B1 recognizes both membrane bound and soluble TREM-1. Also, the monoclonal antibody 6B1 neutralizes the interaction between TREM-1 and its ligand. TREM-1, triggering receptor expressed on myeloid cells 1, TREM1 Aliases Recombinant TREM-1 - IgG1 fusion protein. Immunogen Mouse IgG1