PIN1 anticorps (Internal Region)

N° du produit ABIN233831

Détail du produit anti-PIN1 anticorps

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Chien, Mouton, Singe

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human Pin1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 18 kDa in size corresponding to Pin1 by western blotting in the appropriate cell lysate or extract.  Lysates from 3T3, Jurkat, 293 or HeLa cells, as well as HeLa nuclear extract, are recommended for use as positive controls.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.2 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-PIN1 (ABIN233831)

Lucchetti, Caligiuri, Toffoli, Giordano, Rizzolio: "The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer." dans: PLoS ONE, Vol. 8, Issue 2, pp. e55355, (2013) (PubMed).

La Montagna, Caligiuri, Maranta, Lucchetti, Esposito, Paggi, Toffoli, Rizzolio, Giordano: "Androgen receptor serine 81 mediates Pin1 interaction and activity." dans: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 18, pp. 3415-20, (2013) (PubMed).

Rizzolio, Lucchetti, Caligiuri, Marchesi, Caputo, Klein-Szanto, Bagella, Castronovo, Giordano: "Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1." dans: Cell death and differentiation, Vol. 19, Issue 7, pp. 1152-61, (2012) (PubMed).

Détails sur PIN1

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Autre désignation: PIN1 (PIN1 Produits)

Synonymes: anticorps DOD, anticorps UBL5, anticorps dod, anticorps ubl5, anticorps pin1, anticorps pin1a, anticorps 0610025L01Rik, anticorps D9Bwg1161e, anticorps pin1b, anticorps zgc:73206, anticorps PPIase pin1, anticorps MdPin1, anticorps Pin1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog, anticorps protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog, anticorps peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, anticorps peptidyl-prolyl cis-trans isomerase Pin1, anticorps PIN1, anticorps Pin1, anticorps pin1, anticorps pin1.S, anticorps pin1.L, anticorps ppiD, anticorps PITG_11123, anticorps LOC103419188

Sujet: Pin1 (peptidylprolyl cis/trans isomerase NIMA-interacting 1 protein) is an essential peptidylprolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity.  Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond and also catalyzes pSer/Thr-Pro cis/trans isomerizations.  Pin1 shows a nuclear localization.
Synonyms: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Prolyl isomerase antibody, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody, Protein NIMA interacting 1 antibody, Rotamase Pin1 antibody, UBL 5 antibody

ID gène: 5300, 5453898

UniProt: Q13526