CD31 anticorps (APC)

N° du produit ABIN238441

Cet anticorps Souris Monoclonal détecte spécifiquement CD31 dans FACS. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour CD31 anticorps (APC) (ABIN238441)

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD31 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: MEM-05

Détail du produit anti-CD31 anticorps (APC)

Purification: Size-Exclusion Chromatography

Immunogène: Leukocytes of patient suffering from LGL-type leukaemia

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade BSA (Protease free)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2-8 °C for one month or at -20 °C for longer.

Références pour anticorps anti-CD31 (APC) (ABIN238441)

Soupene, Serikov, Kuypers: "Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells." dans: Journal of lipid research, Vol. 49, Issue 5, pp. 1103-12, (2008) (PubMed).

Détails sur CD31

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Autre désignation: CD31 / PECAM1

Sujet: CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.Synonyms: End °CAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule

ID gène: 9606

UniProt: P16284

Pathways: Regulation of Actin Filament Polymerization